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Abnormal immunological response to Mycobacterium tuberculosis antigens in a patient with chronic myelocytic leukemia and active tuberculosis
Vilá Luis, M; Ríos-Olivares, Eddy; Ríos, Zilka; Meléndez, Myriam; García, Myriam; Pichardo, Betania.
  • Vilá Luis, M; Universidade Central del Caribe. Escola de Medicina. Departamento de Medicina Interna.
  • Ríos-Olivares, Eddy; Universidade Central del Caribe. Escola de Medicina. Departamento de Microbiologia e Imunologia.
  • Ríos, Zilka; Universidade Central del Caribe. Escola de Medicina. Departamento de Microbiologia e Imunologia.
  • Meléndez, Myriam; Universidade Central del Caribe. Escola de Medicina. Departamento de Medicina Interna.
  • García, Myriam; Universidade Central del Caribe. Escola de Medicina. Departamento de Microbiologia e Imunologia.
P. R. health sci. j ; 17(4): 345-52, Dec. 1998. tab, graf
Article in English | LILACS | ID: lil-234848
ABSTRACT
The pathogenic mechanisms of immunosuppression leading to susceptibility of Mycobacterium tuberculosis (MT) infection in chronic myelocytic leukemia (CML) are not clear. To address this issue, we measured the proliferative response, variation of T cell subpopulations (CD4+, CD8+, TCR-V delta 2 and TCR-V beta 8 T cells) and the cytokine profile (IL-1 beta, IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-gamma) after MT stimulation of peripheral blood mononuclear cells (PBMC) in a patient with concomitant CML and active pulmonary tuberculosis. The results were compared to four patients with active pulmonary tuberculosis and no other coexistent diseases. The immunologic response to phytohemagglutinin (PHA) was also evaluated. In contrast to controls, the CML PBMC failed to proliferate in response to MT antigens. Mycobacterium-reactive CD4+, V delta 2 and V beta 8 T cells did not expand after MT stimulation of the CML PBMC. In MT antigens-stimulated cultures from the CML patient, IL-2 was not produced and mild reduction of IL-1 beta and INF-gamma were observed. In contrast, IL-10 was markedly elevated in these cultures. Similarly, PHA-stimulated PBMC from the CML patient showed no expansion of CD4+ and CD8+. T cells. In these cell cultures, INF-gamma concentration in supernatants was decreased and IL-10 was significantly elevated. This study suggests that patients with CML may present a profound immunosuppression of essential cellular and molecular immune effectors, a scenario which might contribute to the development of active tuberculosis. These findings further support the need of establishing immunotherapeutic modalities with potential value for myeloproliferative disorders.
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Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Mycobacterium tuberculosis / Antigens, Bacterial Limits: Adult / Humans / Male Language: English Journal: P. R. health sci. j Journal subject: Medicine Year: 1998 Type: Article

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Index: LILACS (Americas) Main subject: Tuberculosis, Pulmonary / Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Mycobacterium tuberculosis / Antigens, Bacterial Limits: Adult / Humans / Male Language: English Journal: P. R. health sci. j Journal subject: Medicine Year: 1998 Type: Article