Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
Braz. j. med. biol. res
;
32(7): 841-3, July 1999.
Article
in English
| LILACS
| ID: lil-234889
ABSTRACT
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Proto-Oncogene Proteins c-fos
/
Receptors, Fibroblast Growth Factor
/
Adrenal Cortex Neoplasms
/
Adrenocorticotropic Hormone
/
Mitogen-Activated Protein Kinase 1
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1999
Type:
Article
/
Congress and conference
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