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Control of the adrenocortical cell cycle: interaction between FGF2 and ACTH
Armelin, H. A; Lotfi, C. F. P.
  • Armelin, H. A; Universidade de São Paulo. Departamento de Bioquímica. Instituto de Química.
  • Lotfi, C. F. P; Universidade de São Paulo. Departamento de Bioquímica. Instituto de Química.
Braz. j. med. biol. res ; 32(7): 841-3, July 1999.
Article in English | LILACS | ID: lil-234889
ABSTRACT
FGF2 elicits a strong mitogenic response in the mouse Y-1 adrenocortical tumor cell line, that includes a rapid and transient activation of the ERK-MAPK cascade and induction of the c-Fos protein. ACTH, itself a very weak mitogen, blocks the mitogenic response effect of FGF2 in the early and middle G1 phase, keeping both ERK-MAPK activation and c-Fos induction at maximal levels. Probing the mitogenic response of Y-1 cells to FGF2 with ACTH is likely to uncover reactions underlying the effects of this hormone on adrenocortical cell growth
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Proto-Oncogene Proteins c-fos / Receptors, Fibroblast Growth Factor / Adrenal Cortex Neoplasms / Adrenocorticotropic Hormone / Mitogen-Activated Protein Kinase 1 Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1999 Type: Article / Congress and conference

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Full text: Available Index: LILACS (Americas) Main subject: Proto-Oncogene Proteins c-fos / Receptors, Fibroblast Growth Factor / Adrenal Cortex Neoplasms / Adrenocorticotropic Hormone / Mitogen-Activated Protein Kinase 1 Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1999 Type: Article / Congress and conference