Mechanisms of cell transformation induced by polyomavirus
Braz. j. med. biol. res
;
32(7): 861-5, July 1999.
Article
in English
| LILACS
| ID: lil-234892
RESUMO
Polyomavirus is a DNA tumor virus that induces a variety of tumors in mice. Its genome encodes three proteins, namely large T (LT), middle T (MT), and small T (ST) antigens, that have been implicated in cell transformation and tumorigenesis. LT is associated with cell immortalization, whereas MT plays an essential role in cell transformation by binding to and activating several cytoplasmic proteins that participate in growth factor-induced mitogenic signal transduction to the nucleus. The use of different MT mutants has led to the identification of MT-binding proteins as well as analysis of their importance during cell transformation. Studying the molecular mechanisms of cell transformation by MT has contributed to a better understanding of cell cycle regulation and growth control
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Signal Transduction
/
Cell Transformation, Neoplastic
/
Antigens, Polyomavirus Transforming
/
Polyomavirus
/
Papillomavirus Infections
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1999
Type:
Article
/
Congress and conference
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