Genetic susceptibility to HPV infection and cervical cancer
Braz. j. med. biol. res
;
32(7): 915-22, July 1999. tab
Article
in English
| LILACS
| ID: lil-234899
ABSTRACT
Squamous cell carcinoma of the cervix (SCCC) is one of the leading causes of death in developing countries. Infection with high-risk human papillomavirus (HPV) is the major risk factor to develop malignant lesions in the cervix. Polymorphisms of the MHC and p53 genes seem to influence the outcome of HPV infection and progression to SCCC, although controversial data have been reported. MHC are highly polymorphic genes that encode molecules involved in antigen presentation, playing a key role in immune regulation, while p53 is a tumor suppressor gene that regulates cell proliferation. The HPV E6 protein from high-risk types binds p53 and mediates its degradation by the ubiquitin pathway. The role of these polymorphisms in genetic susceptibility to HPV infection and to SCCC remains under investigation
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Papillomaviridae
/
Polymorphism, Genetic
/
Tumor Virus Infections
/
Carcinoma, Squamous Cell
/
Uterine Cervical Neoplasms
/
Genes, p53
/
Cottontail rabbit papillomavirus
/
Papillomavirus Infections
Type of study:
Etiology study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
1999
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
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