The Epidemiological Impact of Antimeningococcal B Vaccination in Cuba
Mem. Inst. Oswaldo Cruz
;
94(4): 433-40, July-Aug. 1999.
Article
in English
| LILACS
| ID: lil-241552
ABSTRACT
The incidence of invasive meningococcal disease (IMD) before (1984-1988) and after (1989-1994), a nationwide intervention with VA-MENGOC-BC vaccination started in 1989, was compared. The prevaccination period incidence density (ID> 8.8/ 105 year-person) was higher than the postvaccination ID (ID< 6.5/ 105 year-person). The percentage proportional differences from the start to the end of each period of ID in the vaccinal period was higher (87 percent) than the prevaccinal (37 percent) with significant differences among vaccinated groups (< 25 years old). A break-point (Chow test) was confirmed by the decrease in the ID between 1989 and 1990 in children under 1 year old, 5-9, 10-14, 15-19 and 50-54 years. Comparison of ID using maps showed a decrease in IMD in all municipalities during the postvaccination period. These findings support the epidemiological impact of VA-MENGOC-BC vaccination in the reduction of IMD morbidity
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bacterial Vaccines
/
Vaccination
/
Meningococcal Infections
/
Neisseria meningitidis
Type of study:
Incidence study
/
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Child
/
Child, preschool
/
Humans
/
Infant, Newborn
Country/Region as subject:
Caribbean
/
Cuba
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
1999
Type:
Article
Affiliation country:
Cuba
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