Olive oil protects against chromosomal aberrations induced by doxorubicin in wistar rat bone marrow cells
Genet. mol. biol
;
22(2): 225-7, jun. 1999. tab
Article
in English
| LILACS
| ID: lil-242205
RESUMO
There is considerable interest in identifying dietary compounds which have the capacity to protect against chromosomal aberrations induced by antitumor agents. Fatty acids and their constituents are able to act as free radical scavengers. Doxorubicin (DXR) is an important chemotherapeutic agent, that also induces chromosome aberrations. Rat bone marrow cells treated simultaneously with olive oil (10 ml/kg body weight) and DXR (90 mg/kg body weight) developed significantly fewer chromosomal aberrations and abnormal metaphases than those treated with DXR alone.
Full text:
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Index:
LILACS (Americas)
Main subject:
Plant Oils
/
Bone Marrow Cells
/
Doxorubicin
/
Chromosome Aberrations
/
Antineoplastic Agents
Limits:
Animals
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
1999
Type:
Article
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