Enfisema pulmonar experimental en la rata: fenómenos inflamatorios y progresión del daño pulmonar / Experimental pulmonary emphysema in the rat: inflammatory phenomena and progression of lung damage
Rev. méd. Chile
;
126(10): 1153-60, oct. 1998. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-242698
ABSTRACT
Background:
Although the hamster model of elastase induced emphysema is well characterized, the rat model has received less attention.Aim:
To evaluate the effect of a single intratracheal elastase dose on lung pathological changes of Sprague-Dawley rats. Material andmethods:
Rats were injected with a single intratracheal elastase dose of 28 U/100 g body weight or saline and studied 7, 15, 30 and 365 days after injection.Results:
Forty percent of rats died in the first 48 hours after injection, six were sacrificed at 7 days, 6 at 15 days, 7 at 30 days and 12 at 365 days. Progressive centroacinar emphysema was found from day 7 after elastase, with a persistent inflammatory reaction in the vicinity of emphysematous areas.Conclusions:
Present findings differ from the panacinar emphysema described in the hamster using a similar elastase dose
Search on Google
Index:
LILACS (Americas)
Main subject:
Pulmonary Emphysema
/
Pancreatic Elastase
Type of study:
Etiology study
/
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1998
Type:
Article
/
Project document
Similar
MEDLINE
...
LILACS
LIS