Risk factors for HTLV-I mother to child transmission: influence of genetic markers
Braz. j. infect. dis
;
2(3): 135-42, Jun. 1998. tab
Article
in English
| LILACS
| ID: lil-243409
RESUMO
This study was designed to evaluate the influence of genetic markers on the seropositivity of offspring of HTLV-I positive mothers in Tumaco, Colombia, an endemic area for HTLV-I infection and a site where there exists a racially mixed population of Black and Caucasian ancestors. 33 HTLV-I seropositive women with at least one offspring were studied. A total of 111 offspring were tested using hemaglutination-inhibition for testing sera for the allotypic markers G1m (1,2,3, 17) and G3m (5, 6, 13, 21). Potential risk factors such as mother's age at child's birth, mother's age at the time of the study, breastfeeding months, TSP vs. asymptomatic HTLV-I carrier, sibship's size, children's age and sex, were not found to be associated with mother to child transmission. Mother's Negroid genetic marker genotype (1, 17, 5, 13/1, 17, 5, ñ 13) was margininally associated with mother to child transmission of HTLV-I (P=0.057; OR=11.97; CI=0.92-155.96).
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Index:
LILACS (Americas)
Main subject:
AIDS Serodiagnosis
/
Human T-lymphotropic virus 1
/
HTLV-I Infections
/
Genetic Markers
/
Risk Factors
/
Infectious Disease Transmission, Vertical
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Female
/
Humans
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Braz. j. infect. dis
Journal subject:
Communicable Diseases
Year:
1998
Type:
Article
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