Bleomycin sensitivity in patients with familial and sporadic polyposis: a pilot study
Genet. mol. biol
;
22(1): 17-20, Mar. 1999. tab, ilus
Article
in English
| LILACS
| ID: lil-243512
RESUMO
Human peripheral blood lymphocytes from 10 patients with familial adenomatous polyposis (FAP) showed a significantly higher incidence of chromatid breaks when compared to cells from 10 normal individuals, after exposure to bleomycin (BLM) during the G2 phase. However, no significant increase in bleomycin sensitivity was observed in lymphocytes from 10 patients with sporadic adenomatous polyps (AP) vs. 10 normal individuals (P = 0.67). Individuals that exhibited an average number of chromatid breaks per cell higher than 0.80 were considered sensitive to the drug. No control showed susceptibility to BLM, as compared to 3 out of 20 patients.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Bleomycin
/
Chromatids
/
Adenomatous Polyposis Coli
/
Antibiotics, Antineoplastic
Type of study:
Diagnostic study
Limits:
Adult
/
Aged80
/
Female
/
Humans
/
Male
Language:
English
Journal:
Genet. mol. biol
Journal subject:
Genetics
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS