Utilidad de la fracción libre del antígeno prostático específico en la detección del cáncer de la próstata / Usefulness of free prostatic specific antigen in the detection of prostate cancer
Rev. méd. Chile
;
127(2): 151-7, feb. 1999. tab, graf
Article
in Spanish
| LILACS
| ID: lil-243773
ABSTRACT
Background:
The predictive value of prostate specific antigen for prostate cancer, when levels are between 4 and 10 ng/ml, is low. Within these range of values, some authors recommend the measurement of the free fraction of the antigen to improve its predictive capacity.Aim:
To evaluate the predictive value of the free fraction in subjects with prostate specific antigen values between 4 and 10 ng/ml. Patients andmethods:
One hundred and forty subjects with prostate specific antigen between 4 and 10 ng/ml were evaluated. All were subjected to transrectal ultrasound examination with biopsies and the free fraction of the antigen was measured by enzyme immuno assay.Results:
Cancer was diagnosed in 36 subjects, all others had a benign prostatic hyperplasia. Mean prostate specific antigen values were 7.4 and 7.1 ng/ml in patients with cancerand hyperplasia, respectively. The percentage of free prostatic specific antigen was 9.8 and 19.8 percent in subjects with cancer and hyperplasia respectively (p <0.001). Using receiver operating characteristic (ROC) curves, a free prostate specific antigen of 13 percent was the best cutoff value for predicting prostate cancer.Conclusions:
In subjects with prostate specific values between 4 and 10 ng/ml, the measurement of the free fraction of this antigen can improve the predictive value of this parameter for the detection of prostate cancer
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Index:
LILACS (Americas)
Main subject:
Prostatic Neoplasms
/
Prostate-Specific Antigen
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1999
Type:
Article
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