Efecto agudo de dobutamina y amrinona sobre la hemodinamia y perfusión esplácnica de pacientes en shock séptico / Acute effect of dobutamine and amrinone on hemodynamics and splanchnic perfusion in septic shock patients
Rev. méd. Chile
; 127(6): 660-6, jun. 1999. tab
Article
in Es
| LILACS
| ID: lil-245307
Responsible library:
CL1.1
RESUMO
Background:
Vasoactive drugs used in the reanimation of septic patients, can modify splanchnic perfusion.Aim:
To compare the effects of dobutamine and amrinone on gastric intramucosal pH (pHi), lactate levels and hemodynamics in surgical patients with compensated septic shock. Patients andmethods:
Fourteen postoperative patients with abdominal sepsis and compensated septic shock (pHi <7.32 or lactate >2.5 mmol/l) were studied in a prospective, randomized, unblinded study. Patients were randomized to receive (Group 1, n=7) dobutamine at 5 µg/Kg/min or (Group 2, n=7) amrinone at 5 µg/Kg/min. Hemodynamic data, arterial lactate and pHi were measured before and 30, 60 and 120 minutes after starting drug infusion.Results:
Both drugs were associated with a decrease in lactate levels. Dobutamine infusion, but not amrinone, increased gastric pHi, as well as cardiac index and oxygen delivery.Conclusions:
An improvement in gastric pHi associated with an increase in oxygen delivery, was observed with dobutamine. Amrinone showed no effect at the fixed, low dose used in the study
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Index:
LILACS
Main subject:
Shock, Septic
/
Amrinone
/
Dobutamine
Type of study:
Clinical_trials
/
Etiology_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Es
Journal:
Rev. méd. Chile
Journal subject:
MEDICINA
Year:
1999
Type:
Article
/
Congress and conference