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Activador del plasminógeno tisular intravenoso en el tratamiento del infarto cerebral agudo: factibilidad, seguridad y eficacia en los primeros dos años de práctica clínica / Intravenous tissue plasminogen activator in acute ischemic stroke: feasibility, safety and efficacy in the first 2 years of clinic practice
Feuerhake Molina, Walter; Chamorro Balart, Hernán; Araya D., Fernando.
  • Feuerhake Molina, Walter; s.af
  • Chamorro Balart, Hernán; s.af
  • Araya D., Fernando; s.af
Rev. méd. Chile ; 127(7): 814-9, jul. 1999. tab, graf
Article in Spanish | LILACS | ID: lil-245387
ABSTRACT

Background:

The only effective therapy for the treatment of acute ischemic stroke is the infusion of tissue plasminogen activator in the first three hours after the onset of symptoms.

Aim:

To report the experience with tissue plasminogen activator infusion in the treatment of acute ischemic stroke. Patients and

methods:

Ten males and 10 females, aged 52 to 85 years old with an acute ischemic stroke, admitted within 89 min after the onset of symptoms were studied. Tissue plasminogen activator was infused following the guidelines designed by the National Institute of Neurological Disorders and Stroke (NINDS). Patients were assessed according to Rankin scale after three months of follow up.

Results:

All patients had normal CAT scans. The delay between the onset of symptoms and the infusion ranged from 75 to 180 min. One patient had a gastrointestinal bleeding due to a gastric ulcer and one patient had a fatal intracranial hemorrhage. After three months of follow up, 38 percent of patients had a good recuperation (Rankin 0 to 1), 33 percent had a mild to moderate disability (Rankin 2 or 3) and 14 percent had a moderate to severe disability (Rankin 4). There was a 15 percent mortality.

Conclusions:

This series show that treatment of acute ischemic stroke with tissue plasminogen activator is feasible and safe. The obtained results are similar to those reported abroad
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Index: LILACS (Americas) Main subject: Cerebral Infarction / Tissue Plasminogen Activator Type of study: Diagnostic study / Etiology study / Practice guideline / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 1999 Type: Article

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Index: LILACS (Americas) Main subject: Cerebral Infarction / Tissue Plasminogen Activator Type of study: Diagnostic study / Etiology study / Practice guideline / Risk factors Limits: Female / Humans / Male Language: Spanish Journal: Rev. méd. Chile Journal subject: Medicine Year: 1999 Type: Article