Autoimmune and non-autoimmune thyroid diseases have different patterns of cellular HLA class II expression
São Paulo med. j
;
117(4): 161-4, July 1999.
Article
in English
| LILACS
| ID: lil-247140
RESUMO
CONTEXT Surface HLA-DR antigen is usually only expressed by antigen-presenting cells (APC). In autoimmune thyroid disease, follicle cells function as APC, thus expressing HLA-DR. However, non-autoimmune thyroid diseases may also express surface class II antigens. OBJECTIVE:
To evaluate the presence and pattern of HLA class II expression in autoimmune and non-autoimmune thyroid disorders.DESIGN:
Retrospective histopathological and immunohistochemical analysis. LOCATION Referral center, university hospital. SAMPLE Ten histologically normal thyroids, 11 GravesÆ disease, 7 HashimotoÆs thyroiditis, 10 atoxic multinodular goiter and 3 toxic adenomas were analyzed by immunohistochemistry, using a monoclonal antibody anti-HLA-DR. MAIN MEASUREMENTS The presence of these antigens in thyroid follicular cells and their relation to inflammatory infiltrate was evaluated. The pattern of HLA-DR expression in thyroid follicular cells was analyzed membrane, cytoplasmic or both.RESULTS:
Although HLA-DR antigens were sparsely present in one of the 8 normal thyroids, in 6 of the 9 atoxic multinodular goiter and in 2 of the 3 toxic adenomas a net positivity could be seen in large areas. In all 5 HashimotoÆs thyroiditis and in 7 of the 10 GravesÆ disease cases. This expression occurred in follicle cells either in contact with inflammatory cells or not. In non-autoimmune thyroid disease, HLA-DR positivity was essentially cytoplasmic, whereas in GravesÆ disease and Hashimoto thyroiditis it was mainly in cell membranes.CONCLUSIONS:
It is suggested that the HLA class II expression on the surface of follicle cells could be related to auto-antigen presentation to the immune system by these cells, leading to inflammation
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Thyroid Diseases
/
Thyroiditis, Autoimmune
/
HLA-DR Antigens
/
Genes, MHC Class II
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
São Paulo med. j
Journal subject:
Cirurgia Geral
/
Cincia
/
Ginecologia
/
Medicine
/
Medicina Interna
/
Obstetr¡cia
/
Pediatria
/
Sa£de Mental
/
Sa£de P£blica
Year:
1999
Type:
Article
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