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Vascular changes after cardiopulmonary bypass and ischemic cardiac arrest: roles of nitric oxide synthase and cyclooxygenase
Sellke, F. W.
  • Sellke, F. W; Harvard Medical School. Division of Cardiothoracic Surgery. Department of Surgery.
Braz. j. med. biol. res ; 32(11): 1345-52, Nov. 1999.
Article in English | LILACS | ID: lil-248428
RESUMO
Cardiac surgery involving ischemic arrest and extracorporeal circulation is often associated with alterations in vascular reactivity and permeability due to changes in the expression and activity of isoforms of nitric oxide synthase and cyclooxygenase. These inflammatory changes may manifest as systemic hypotension, coronary spasm or contraction, myocardial failure, and dysfunction of the lungs, gut, brain and other organs. In addition, endothelial dysfunction may increase the occurrence of late cardiac events such as graft thrombosis and myocardial infarction. These vascular changes may lead to increased mortality and morbidity and markedly lengthen the time of hospitalization and cost of cardiac surgery. Developing a better understanding of the vascular changes operating through nitric oxide synthase and cyclooxygenase may improve the care and help decrease the cost of cardiovascular operations.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Cardiopulmonary Bypass / Prostaglandin-Endoperoxide Synthases / Myocardial Ischemia / Nitric Oxide Synthase / Coronary Vessels / Heart Arrest, Induced Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1999 Type: Article / Congress and conference

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Full text: Available Index: LILACS (Americas) Main subject: Cardiopulmonary Bypass / Prostaglandin-Endoperoxide Synthases / Myocardial Ischemia / Nitric Oxide Synthase / Coronary Vessels / Heart Arrest, Induced Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 1999 Type: Article / Congress and conference