Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;32(12): 1525-8, Dec. 1999. graf
Article
in En
| LILACS
| ID: lil-249378
Responsible library:
BR1.1
ABSTRACT
Diabetic nephropathy (DN) is characterized structurally by progressive mesangial deposition of extracellular matrix (ECM). Transforming growth factor-ß (TGF-ß) is considered to be one of the major cytokines involved in the regulation of ECM synthesis and degradation. Several studies suggest that an increase in urinary TGF-ß levels may reflect an enhanced production of this polypeptide by the kidney cells. We evaluated TGF-ß in occasional urine samples from 14 normal individuals and 23 patients with type 2 diabetes (13 with persistent proteinuria >500 mg/24 h, DN, 6 with microalbuminuria, DMMA, and 4 with normal urinary albumin excretion, DMN) by enzyme immunoassay. An increase in the rate of urinary TGF-ß excretion (pg/mg UCreat.) was observed in patients with DN (296.07 + or - 330.77) (P<0.001) compared to normal individuals (17.04 + or - 18.56) (Kruskal-Wallis nonparametric analysis of variance); however, this increase was not observed in patients with DMMA (25.13 + or - 11.30) or in DMN (18.16 + or - 11.82). There was a positive correlation between the rate of urinary TGF-ß excretion and proteinuria (r = 0.70, a = 0.05) (Pearson's analysis), one of the parameters of disease progression.
Full text:
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Index:
LILACS
Main subject:
Transforming Growth Factor beta
/
Diabetes Mellitus, Type 2
/
Diabetic Nephropathies
Limits:
Adult
/
Humans
Language:
En
Journal:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Journal subject:
BIOLOGIA
/
MEDICINA
Year:
1999
Type:
Article
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Congress and conference