IgG recognizing 21-24 kDa and 30-33 kDa tachyzoite antigens show maximum avidity maturation during natural and accidental human toxoplasmosis
Rev. Inst. Med. Trop. Säo Paulo
;
41(5): 297-303, Sept.-Oct. 1999. graf, tab
Article
in English
| LILACS
| ID: lil-250203
RESUMO
We describe the avidity maturation of IgGs in human toxoplasmosis using sequential serum samples from accidental and natural infections. In accidental cases, avidity increased continuously throughout infection while naturally infected patients showed a different profile. Twenty-five percent of sera from chronic patients having specific IgM positive results could be appropriately classified using exclusively the avidity test data. To take advantage of the potentiality of this technique, antigens recognized by IgG showing steeper avidity maturation were identified using immunoblot with KSCN elution. Two clusters of antigens, in the ranges of 21-24 kDa and 30-33 kDa, were identified as the ones that fulfill the aforementioned avidity characteristics
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Toxoplasma
/
Immunoglobulin G
/
Toxoplasmosis
/
Antibody Affinity
/
Antigens, Protozoan
Type of study:
Observational study
/
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Rev. Inst. Med. Trop. Säo Paulo
Journal subject:
Tropical Medicine
Year:
1999
Type:
Article
Affiliation country:
Uruguay
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