Structure-biological activity relationship of synthetic trihydroxilated chalcones
Rev. microbiol
;
29(4): 307-10, out.-dez. 1998. ilus, tab
Article
in English
| LILACS
| ID: lil-251742
ABSTRACT
The bacteriostatic activity of 2',4',2'-trihydroxychalcone; 2',4',3'-trihydroxychalcone and 2',4',4'-trihydroxychalcone, prepared by condensation of 2,4-dihydroxyacetophenone and benzaldehyde substituted, against "Staphylococcus aureus" ATCC 25923 was assayed by agar plate method. The three compounds presented important inhibition halos. In order to elucidate structure-activity relationships, the minimal inhibitory concentrations against "S. aureus"were determined by the broth dilution method and the results obtained were compared to that of 2',4'-(OH)2>MIC 2',4',4'-(OH)3>>MIC 2',4',2-(OH)3. these results showed that the introduction of an electron donating group (-OH) in the aromatic B-ring causes an increase in bioactivity, and that the intensity of action depends on the position of the OH substitute.
Full text:
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Index:
LILACS (Americas)
Main subject:
Staphylococcus aureus
/
Chalcone
Language:
English
Journal:
Rev. microbiol
Journal subject:
Microbiology
Year:
1998
Type:
Article
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