Spontaneous Kanamycin-resistant Escherichia coli mutant with altered periplasmic oligopeptide permease protein (OPPA) and impermeability to aminoglycosides
Rev. microbiol
;
30(2): 153-6, abr.-jun. 1999. ilus, tab
Article
in Portuguese, English
| LILACS
| ID: lil-257213
ABSTRACT
A spontaneous kanamycin-resistant Escherichia coli mutant, showing cross resitance to five other aminoglycosides and absence of the OppA protein was isolated. [3H]- dihydrostreptomycin uptake is reduced in this mutant, implying that the oligopeptide transport system in involved in accumulation of aminoglucosides, although apparently not related with aminoglycoside permeability alteration due to bacterial adaptation to osmotic changes.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Oligopeptides
/
Membrane Transport Proteins
/
Kanamycin Resistance
/
Proteins
/
Periplasm
/
Escherichia coli
/
Aminoglycosides
Language:
English
/
Portuguese
Journal:
Rev. microbiol
Journal subject:
Microbiology
Year:
1999
Type:
Article
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