Hepatotoxicidad por amoxicilina/ácido clavulánico: caso clínico / Hepatotoxixity associated to the use of amoxicillin clavulanic acid
Rev. méd. Chile
;
127(12): 1487-91, dic. 1999. ilus, graf
Article
in Spanish
| LILACS
| ID: lil-258074
ABSTRACT
We report a 72 years old diabetic male that, after the use of combined amoxicillin-clavulanic acid, developed pruritus and jaundice. Liver function tests showed serum total bilirubin of 4.3 mg/dL aspartate aminotransferase 140 U/l (normal <35 U/L), alanine aminotransferase 470 U/L (normal <40) and alkaline phosphatases of 400 U/L (normal <100). Serology for hepatitis A, B and C viruses was negative, ERCP showed a normal biliary tree and liver biopsy disclosed a cholestatic hepatitis. Ursodeoxycholic was started to relieve pruritus. Liver function tests improved shortly thereafter, suggesting that this drug may be useful in the treatment of drug induced cholestasis
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Clavulanic Acid
/
Chemical and Drug Induced Liver Injury
/
Amoxicillin
Type of study:
Diagnostic study
/
Risk factors
Limits:
Aged
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
1999
Type:
Article
Affiliation country:
Chile
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