Interactions between cationic liposomes and drugs or biomolecules
An. acad. bras. ciênc
;
72(1): 39-43, mar. 2000.
Article
in English
| LILACS
| ID: lil-259476
RESUMO
Multiple uses for synthetic cationic liposomes composed of dioctadecyldimethylammonium bromide (DODAB) bilayer vesicles are presented. Drugs or biomolecules can be solubilized or incorporated in the cationic bilayers. The cationic liposomes themselves can act as antimicrobial agents causing death of bacteria and fungi at concentrations that barely affect mammalian cells in culture. Silica particles or coverage with DODAB bilayers or polystyrene microspheres can be functionalized by phospholipid monolayers. Negatively charged antigenic proteins can be carried by the cationic liposomes which generate a remarkable immunoadjuvant action. Nucleotides or DNA can be physically adsorbed to the cationic liposomes to be transferred to mammalian cells for gene therapy. An overview of the interactions between DODAB vesicles and some biomolecules or drugs clearly points out their versatility for useful applications in a near future
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Surface-Active Agents
/
Quaternary Ammonium Compounds
/
Liposomes
/
Anti-Infective Agents
Language:
English
Journal:
An. acad. bras. ciênc
Journal subject:
Science
Year:
2000
Type:
Article
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