Effect of n-acetylcysteine in a random skin flap after administration of nicotine, in the rat
Folha méd
;
117(3): 209-11, nov.-dez. 1998. ilus, graf
Article
in English
| LILACS
| ID: lil-260507
RESUMO
This study analyzed the perfusion of a random skin flap, after nicotine injection and administration of N-acetylcysteine (NAC). A skin flap was elevated after 6 weeks of nicotine administartion and the percentage of necrosis was determined thereafter, as well as malondialdehyde (MDA) in 4 selected skin areas and in serum. Both nicotine and NAC elicited elevation in MDA levels in the skin samples. Nicotine also led to elevation in serum MDA levels and in the percentage of flap necrosis. NAC did not improve the viability of the flap.
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Index:
LILACS (Americas)
Main subject:
Acetylcysteine
/
Surgical Flaps
/
Free Radical Scavengers
/
Nicotinic Agonists
/
Nicotine
Limits:
Animals
Language:
English
Journal:
Folha méd
Journal subject:
Medicine
Year:
1998
Type:
Article
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