Müllerian adenosarcoma of the uterus with sarcomatous overgrowth following tamoxifen treatment for breast cancer
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
55(1): 17-20, Jan.-Feb. 2000. ilus
Article
in English
| LILACS
| ID: lil-260703
ABSTRACT
Müllerian adenosarcoma with sarcomatous overgrowth presented by a 52-year-old female patient after adjuvant tamoxifen treatment for breast carcinoma is described. The diagnosis was made on histological basis after curettage and complementary total hysterectomy with bilateral salpingo-oophorectomy. The immunohistochemical study showed high expression of estrogen receptors in the epithelial component of the lesion and irregularly positive findings in the stroma. The proliferative activity evaluated by Ki-67 immunoexpression was higher in the stroma than the epithelium. Some of the stromal cells showed rhabdomyoblastic differentiation. The association of tamoxifen use and development of mesenchymal neoplasms is discussed.
Full text:
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Index:
LILACS (Americas)
Main subject:
Tamoxifen
/
Uterine Neoplasms
/
Breast Neoplasms
/
Adenosarcoma
/
Antineoplastic Agents, Hormonal
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2000
Type:
Article
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