Nutrición molecular, papel del sistema PPAR en el metabolismo lipídico y su importancia en obesidad y diabetes mellitus / Molecular nutrition: regulation of lipid metabolism by peroxisome proliferator activated receptors, PPAR: their relatioship to obesity and diabetes mellitus
Rev. méd. Chile
;
128(4): 437-46, abr. 2000. ilus, graf
Article
in Spanish
| LILACS
| ID: lil-263715
ABSTRACT
PPARs are transcription factors belonging to the super family of hormonal receptors. Their activity is regulated by fibrates, thiazolidinediones, certain anti inflammatory drugs and fatty acid derivatives, present in food. PPAR isoforms play a central role in lipid homeostasis, regulating anabolic (PPARg) and catabolic (PPARa) pathways of lipid metabolism. Additionally, these receptors participate in glucose homeostasis, influence cellular proliferation and differentiation and participate in inflammatory processes. The effects of PPARs on oxidative substrate partitioning suggests that they have a relevant role in the development of obesity and insulin resistance
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Lipid Peroxidation
/
Peroxisome Proliferators
/
Diabetes Mellitus
/
Obesity
Limits:
Humans
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2000
Type:
Article
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