Effects of adrenalectomy and adrenal enucleation on liquid gastric emptying in rats

RESUMO

The effects of adrenalectomy and adrenal enucleation on liquid gastric emptying were studied in male Wistar rats that were adrenalectomized, adrenal enucleated (AE) or sham operated (SH). The animals in the first group had free access to a 1 percent NaCl solution (ADS), while the animals in the second and third groups were divided into two subgroups, which ingested either tap water (AEW, SHW) or 1 percent NaCl solution (AES, SHS). The gastric emptying study was performed on the 16th post-operative day. Three test meals labeled with phenol red (6 mg/dl) were used (0.9 percent NaCl, 1.8 percent NaCl and 5 percent glucose). Percent gastric retention was determined 10 min after orogastric infusion of the NaCl test meals and 15 min after the glucose meal. Gastric retention of the ADS subgroup was significantly lower (P<0.01) (median = 19.8 percent vs 25.5 percent for SHW, vs 31.9 percent for SHS, vs 25.7 percent for AEW, and vs 27.1 percent for AES) for the 0.9 percent NaCl test meal and for the 1.8 percent NaCl test meal (33.5 percent for ADS vs 47.5 percent for AEW and 50.6 percent for AES). When 5 percent glucose was used as a test meal, gastric retention was similar for all subgroups. These results suggest that ablation of the adrenal cortex results in increased gastric emptying of an isosmolar NaCl meal