Disfunción endotelial como alteración primaria en las patologías vasculares / Endothelial dysfunction as a primary alteration in vascular diseases
Rev. méd. Chile
;
128(6): 659-70, jun. 2000. ilus, tab
Article
in Spanish
| LILACS
| ID: lil-268152
RESUMO
Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In addition, the endothelium may increase the release of NO in response to humoral stimulation by vasoactive substances such as acetylcholine, bradikinin or substance P. Although the endothelium releases a number of products, no single blood test has yet proved useful to determine normal endothelial function or as early abnormalities. The most useful test of endothelial function relies on the meassurement of endothelium-dependent dilatation in response to pharmacological or physiologic stimuli. The alteration of this response is known as endothelial dysfunction and has been observed in a variety of circumstances related to cardiovascular risk. This review summarizes the evidence that sustains this association and emphasizes the clinical utility of assessing endothelial function presenting two clinical cases of hypercholesterolemia in which a high-resolution vascular ultrasound in the braquial artery was used
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Endothelium
/
Atherosclerosis
/
Hypercholesterolemia
Type of study:
Etiology study
/
Risk factors
Limits:
Adult
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Spanish
Journal:
Rev. méd. Chile
Journal subject:
Medicine
Year:
2000
Type:
Article
/
Project document
Affiliation country:
Chile
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