Effect of combined treatment with calcitonin on bone densitometry of patients with treated hypothyroidism
Rev. Assoc. Med. Bras. (1992, Impr.)
;
46(2): 177-81, abr.-jun. 2000. tab, graf
Article
in English
| LILACS
| ID: lil-268370
RESUMO
INTRODUCTION:
Thyroid hormones (TH) may affect bone metabolism and turnover, inducing a loss of bone mass among hyperthyroid and in hypothyroid patients under hormone replacement treatment. Thyroid dysfunction leads to changes in the dynamics of parathyroid hormone (PTH) and calcitonin (CT) secretion.OBJECTIVE:
The objective of the study was to determine the usefulness of CT as adjuvant therapy in the prevention of bone loss during the treatment of hypothyroidism. MATERIAL ANDMETHODS:
We studied 16 female patients with recently diagnosed primary hypothyroidism, divided into two groups group G1 (n=8) submitted to treatment with thyroxine (L-T4), and Group 2 (n=8) that, in addition to being treated with L-T4, received a nasal CT spray. All patients were submitted to determination of TSH, free T4, bone mineral densitometry (BMD) and total bone calcium (TBC) at the time of diagnosis, after 6 to 9 months of treatment, and after 12 months of treatment.RESULTS:
No statistical significant differences were detected in either group between the total BMD values obtained for the femur and lumbar spine before and after treatment. However, group G1 presented a statistical significant TBC loss after 12 months of treatment compared to initial values. In contrast, no TBC loss was observed in the group treated with LT-4 in combination with CT, a fact that may suggest that CT was responsible for the lower bone reabsorption during treatment of hypothyroidism.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Osteoporosis
/
Calcitonin
/
Bone Density
/
Hypothyroidism
Type of study:
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
Journal:
Rev. Assoc. Med. Bras. (1992, Impr.)
Journal subject:
EducaÆo em Sa£de
/
GestÆo do Conhecimento para a Pesquisa em Sa£de
/
Medicine
Year:
2000
Type:
Article
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