¿Contribuye el TNF-alfa a la fisiopatolog'ia de las hepatopatias?

Ghanem, Ghanem; Ghisolfi, Cecilia; Scorticati, Camila; Perazzo, J. C; Bengochea, Laura

¿Contribuye el TNF-alfa a la fisiopatolog'ia de las hepatopatias? / Does TNF-alpha contribute to liver disease physiopathology?

Ghanem, Ghanem; Ghisolfi, Cecilia; Scorticati, Camila; Perazzo, J. C; Bengochea, Laura.

Ghanem, Ghanem; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Fisiopatología.
Ghisolfi, Cecilia; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Fisiopatología.
Scorticati, Camila; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Fisiopatología.
Perazzo, J. C; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Fisiopatología.
Bengochea, Laura; Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Cátedra de Fisiopatología.

Acta gastroenterol. latinoam ; 30(3): 151-4, jul. 2000. tab, graf

Article in Spanish | LILACS | ID: lil-269917

RESUMO

RESUMO

The aim of the present paper is to establish the possible role of serum TNF in the pathophysiology of three experimental models of liver injury paracetamol intoxication, cholestasis followed by paracetamol intoxication and cholestasis. We concluded that under our experimental conditions the serum TNF-alpha levels were not responsible for the inflammatory phenomena described in our previous paper as apopt.

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Animals; Male; Rats; Acetaminophen/toxicity; Analgesics, Non-Narcotic/toxicity; Cholestasis/chemically induced; Kidney Diseases/physiopathology; Tumor Necrosis Factor-alpha/physiology; Acetaminophen/blood; Alanine Transaminase/blood; Analgesics, Non-Narcotic/blood; Analysis of Variance; Aspartate Aminotransferases/blood; Bilirubin/blood; Bilirubin/metabolism; Case-Control Studies; Cholestasis/physiopathology; Liver/drug effects; Rats, Wistar; Tumor Necrosis Factor-alpha/chemistry

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Index: LILACS (Americas) Main subject: Cholestasis / Tumor Necrosis Factor-alpha / Analgesics, Non-Narcotic / Kidney Diseases / Acetaminophen Type of study: Observational study / Prognostic study Limits: Animals Language: Spanish Journal: Acta gastroenterol. latinoam Journal subject: Gastroenterology Year: 2000 Type: Article

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