Increased fetal hemoglobin levels in patients infected with human immunodeficiency virus (HIV1/2)
Braz. j. med. biol. res
;
33(11): 1313-5, Nov. 2000. tab
Article
in English
| LILACS
| ID: lil-273208
ABSTRACT
Fetal hemoglobin was measured in HIV1/2 patients under treatment with combined therapy (zidovudine and a protease inhibitor). A total of 143 patients and 103 normal individuals were investigated by the quantitative method of Betke and the semi-quantitative acid elution method of Kleihauer. In the normal person, hemoglobin F makes up less than 1 percent and an increase higher than 1.5 percent was observed in 21.4 percent of HIV patients by the method of Betke and in 24.8 percent of HIV-infected patients by the method of Kleihauer. The quantitative biochemical method of Betke showed that the populations were significantly different (two-tailed Mann-Whitney test). The reason for this hemoglobin F increase might be ascribed to the effect of zidovudine or to direct viral action on gamma chain expression. The finding of a higher F cell frequency indicated by the method of Kleihauer rather suggests that there is an increased F cell clone proliferation rather than an increase in hemoglobin F level in every cell
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Fetal Hemoglobin
/
HIV Infections
Type of study:
Observational study
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2000
Type:
Article
/
Congress and conference
Affiliation country:
Brazil
Institution/Affiliation country:
Instituto Adolfo Lutz/BR
/
Universidade Federal do Rio Grande do Norte/BR
/
Universidade de Säo Paulo/BR
Similar
MEDLINE
...
LILACS
LIS