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Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer
Burbano, R. R; Medeiros, A. C; Mello, A. A; Lemos, J. A; Bahia, M. O; Casartelli, C.
  • Burbano, R. R; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Biologia. BR
  • Medeiros, A. C; Universidade Federal da Paraíba. Departamento de Biologia Molecular. Joäo Pessoa. BR
  • Mello, A. A; Universidade Federal da Paraíba. Departamento de Biologia Molecular. Joäo Pessoa. BR
  • Lemos, J. A; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Genética. BR
  • Bahia, M. O; Universidade Federal do Pará. Centro de Ciências Biológicas. Departamento de Patologia. BR
  • Casartelli, C; Universidade de Säo Paulo. Faculdade de Medicina de Ribeirao Preto. Departamento de Genética. Ribeiräo Preto. BR
Braz. j. med. biol. res ; 33(11): 1325-8, Nov. 2000. tab, ilus
Article in English | LILACS | ID: lil-273220
Responsible library: BR1.1
ABSTRACT
Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Genes, p53 / Polymorphism, Single-Stranded Conformational Limits: Adolescent / Adult / Female / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Paraíba/BR / Universidade Federal do Pará/BR / Universidade de Säo Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Breast Neoplasms / Genes, p53 / Polymorphism, Single-Stranded Conformational Limits: Adolescent / Adult / Female / Humans Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Federal da Paraíba/BR / Universidade Federal do Pará/BR / Universidade de Säo Paulo/BR