Investigation of single-strand conformational polymorphism of the TP53 gene in women with a family history of breast cancer
Braz. j. med. biol. res
;
33(11): 1325-8, Nov. 2000. tab, ilus
Article
in English
| LILACS
| ID: lil-273220
ABSTRACT
Breast cancer in families with germ line mutations in the TP53 gene has been described in the medical literature. Mutation screening for susceptibility genes should allow effective prophylactic and preventive measures. Using single-strand conformational polymorphism, we screened for mutations in exons 5, 6, 7 and 8 of gene TP53 in the peripheral blood of 8 young non-affected members (17 to 36 years old) of families with a history of breast cancer. Studies of this type on young patients (mean age, 25 years) are very rare in the literature. The identification of these mutations would contribute to genetic counseling of members of families with predisposition to breast cancer. The results obtained did not show any polymorphism indicating mutation. In our sample, the familial tumorigenesis is probably related to other gene etiologies
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Breast Neoplasms
/
Genes, p53
/
Polymorphism, Single-Stranded Conformational
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Female
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal da Paraíba/BR
/
Universidade Federal do Pará/BR
/
Universidade de Säo Paulo/BR
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