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Effects of depot medroxyprogesterone acetate on the calcium metabolism of adult ovariectomized rats
Roveri, Eriberto A; Chapo, Gustavo; Grappiolo, Irene; Puche, Rodolfo C.
  • Roveri, Eriberto A; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osea. Rosario. AR
  • Chapo, Gustavo; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osea. Rosario. AR
  • Grappiolo, Irene; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osea. Rosario. AR
  • Puche, Rodolfo C; Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Biología Osea. Rosario. AR
Medicina (B.Aires) ; 60(4): 482-6, 2000. tab
Article in English | LILACS | ID: lil-273474
ABSTRACT
This paper describes experiments designed to test the effect of depot medroxyprogesterone acetate (DMPA) on calcium metabolism of adult ovariectomized rats. The 24 animals were randomly assigned to control or treated groups. Treated rats received 15 mg of DMPA i.m. per week, during four or twelve weeks. Controls received solvent alone. The variables characterizing the metabolism of Ca (daily rates of intestinal absorption and excretion, bone accretion and resorption and the sizes of the exchangeable pools and their rate constants) were measured with the aid of 45Ca according to Aubert and Milhaud. No effects were observed at four weeks of treatment. After twelve weeks, treatment produced serum levels of 46.5 ñ 5.6 nmoles of medroxyprogesterone/L, reduction of bone turnover (Ca accretion and resorption rates) and of the size of the slow exchanging Ca compartment. The increase in true Ca intestinal absorption was compensated by the increased endogenous fecal Ca excretion. The mass of body Ca was not affected by treatment.
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Index: LILACS (Americas) Main subject: Progestins / Ovariectomy / Calcium / Medroxyprogesterone Acetate Limits: Animals Language: English Journal: Medicina (B.Aires) Journal subject: Medicine Year: 2000 Type: Article Affiliation country: Argentina Institution/Affiliation country: Universidad Nacional de Rosario/AR

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Index: LILACS (Americas) Main subject: Progestins / Ovariectomy / Calcium / Medroxyprogesterone Acetate Limits: Animals Language: English Journal: Medicina (B.Aires) Journal subject: Medicine Year: 2000 Type: Article Affiliation country: Argentina Institution/Affiliation country: Universidad Nacional de Rosario/AR