Analise dos fatores de risco da doença vascular do enxerto em pacientes assintomáticos após transplante cardíaco / Analysis of the risk factors for allograft vasculopathy in asymptomatic patients after cardiac transplantation
Arq. bras. cardiol
;
75(5): 413-28, Nov. 2000.
Article
in Portuguese, English
| LILACS
| ID: lil-273497
ABSTRACT
OBJECTIVE:
To study the influence of immune and nonimmune risk factors on the development of allograft vasculopathy after cardiac transplantation.METHODS:
We studied 39 patients with a mean age of 46 + or - 12 years. The following variables were analyzed weight (kg), body mass index (kg/m²), donor's age and sex, rejection episodes in the first and second years after transplantation, systolic and diastolic blood pressures (mmHg), total cholesterol and fractions (mg/dL), triglycerides (mg/dL), diabetes, and cytomegalovirus infection. The presence of allograft vasculopathy was established through coronary angiography.RESULTS:
Allograft vasculopathy was observed in 15 (38 percent) patients. No statistically significant difference was observed between the two groups in regard to hypertension, cytomegalovirus infection, diabetes, donor's sex and age, rejection episodes in the first and second years after transplantation, and cholesterol levels. We observed a tendency toward higher levels of triglycerides in the group with disease. Univariate and multivariate analyses showed statistically significant differences between the two groups when we analyzed the body mass index (24.53 + or - 4.3 versus 28.11 + or - 4.6; p=0.019).CONCLUSION:
Body mass index was an important marker of allograft vasculopathy in the population studied
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Heart Transplantation
/
Coronary Disease
/
Graft Rejection
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged80
/
Child
/
Female
/
Humans
Country/Region as subject:
South America
/
Brazil
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de São Paulo/BR
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