Vaccine-associated paralytic poliomyelitis: a case report of domiciliary transmission
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
55(3): 101-4, May-June 2000. tab
Article
in English
| LILACS
| ID: lil-273571
RESUMO
Poliomyelitis associated with live strain vaccine is defined as the paralytic form of the acute anterior poliomyelitis related to the vaccine strain. Since these strains behave similarly to the wild-type virus, we can differentiate, epidemiologically, two types of vaccine-associated poliomyelitis cases in which the patient was vaccinated and cases in which the patient had had contact with vaccinated individuals. We herein present the case of an unvaccinated child, with a clinical picture of an acute anterior poliomyelitis associated with the live strain vaccine, whose brother received the Sabin vaccine 20 days before the onset of the symptoms. Vaccine strain of the type 3 poliovirus was isolated in fecal culture and a presented mutation in nucleotide 472 (C(r)U) in the 5' non-coding region, which is strongly related to the higher strain virulence
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Poliomyelitis
/
Poliovirus Vaccine, Oral
/
Disease Transmission, Infectious
Type of study:
Diagnostic study
/
Risk factors
Limits:
Child, preschool
/
Humans
/
Infant
/
Male
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Säo Paulo/BR
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