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Congenital destructive hemispheric lesions and epilepsy: clinical features and relevance of associated hippocampal atrophy
Teixeira, Ricardo A; Leone, Andrea A. A; Honorato, Donizeti C; Damasceno, Benito P; Guerreiro, Carlos A. M; Cendes, Fernando.
  • Teixeira, Ricardo A; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
  • Leone, Andrea A. A; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
  • Honorato, Donizeti C; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
  • Damasceno, Benito P; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
  • Guerreiro, Carlos A. M; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
  • Cendes, Fernando; Universidade Estadual de Campinas. Faculdade de Ciências Médicas. Departamento de Neurologia. Campinas. BR
Arq. neuropsiquiatr ; 58(4): 990-1001, Dec. 2000.
Article in English | LILACS | ID: lil-273837
RESUMO
We studied the clinical, EEG and MRI findings in 19 patients with epilepsy secondary to congenital destructive hemispheric insults. Patients were divided in two groups 10 with cystic lesions (group 1), and 9 with atrophic lesions (group 2). Seizure and EEG features, as well as developmental sequelae were similar between the two groups, except for the finding that patients of group 2 more commonly presented seizures with more than one semiological type. MRI showed hyperintense T2 signal extending beyond the lesion in almost all patients of both groups, and it was more diffuse in group 2. Associated hippocampal atrophy (HA) was observed in 70 percent of group 1 patients and 77.7 percent of group 2, and it was not correlated with duration of epilepsy or seizure frequency. There was a good concordance between HA and electroclinical localization. The high prevalence of associated HA in both groups suggests a common pathogenesis with the more obvious lesion. Our findings indicate that in some of these patients with extensive destructive lesions, there may be a more circumscribed epileptogenic area, particularly in those with cystic lesions and HA, leading to a potential rationale for effective surgical treatment
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Central Nervous System Cysts / Epilepsy / Hippocampus Type of study: Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR

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Full text: Available Index: LILACS (Americas) Main subject: Central Nervous System Cysts / Epilepsy / Hippocampus Type of study: Risk factors Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Arq. neuropsiquiatr Journal subject: Neurology / Psychiatry Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade Estadual de Campinas/BR