Double-blind clonazepam vs placebo in panic disorder treatment
Arq. neuropsiquiatr
;
58(4): 1025-9, Dec. 2000.
Article
in English
| LILACS
| ID: lil-273842
ABSTRACT
OBJECTIVE:
To assess the effectiveness of clonazepam, in a fixed dose (2 mg/day), compared with placebo in the treatment of panic disorder patients.METHOD:
24 panic disorder patients with agoraphobia were randomly selected. The diagnosis was obtained using the structured clinical interview for DSM-IV . All twenty-four subjects were randomly assigned to either treatment with clonazepam (2 mg/day) or placebo, during 6 weeks. Efficacy assessments included change from baseline in the number of panic attacks; CGI scores for panic disorder; Hamilton rating scale for anxiety; and panic associated symptoms scale.RESULTS:
At the therapeutic endpoint, only one of 9 placebo patients (11.1 percent) were free of panic attacks, compared with 8 of 13 (61.5 percent) clonazepam patients (Fisher exact test; p=0,031).CONCLUSION:
the results provide evidence for the efficacy of clonazepam in panic disorder patients
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Panic Disorder
/
Clonazepam
/
GABA Modulators
/
Agoraphobia
Type of study:
Controlled clinical trial
/
Qualitative research
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Federal University of Rio de Janeiro/BR
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