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Monitorizaçäo ambulatorial da pressäo arterial e microalbuminúria em diabéticos insulino-dependentes normotensos / Ambulatory blood pressure monitoring and microalbuminuria in normotensive subjects with insulin-dependent diabetes mellitus
Cohen, Cesar Nissan; Albanesi Filho, Francisco Manes; Gonçalves, Maria de Fátima; Gomes, Marília de Brito.
  • Cohen, Cesar Nissan; Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. BR
  • Albanesi Filho, Francisco Manes; Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. BR
  • Gonçalves, Maria de Fátima; Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. BR
  • Gomes, Marília de Brito; Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Rio de Janeiro. BR
Arq. bras. cardiol ; 75(3): 195-204, set. 2000. tab
Article in Portuguese, English | LILACS | ID: lil-274140
RESUMO

OBJECTIVE:

To assess the association between microalbuminuria with ambulatory blood pressure monitoring in normotensive individuals with insulin-dependent diabetes mellitus.

METHODS:

Thirty-seven patients underwent determination of the rate of urinary excretion of albumin through radioimmunoassay and ambulatory blood pressure monitoring. Their mean age was 26.5 + or - 6.7 years, and the mean duration of their disease was 8 (1-34) years. Microalbuminuria was defined as urinary excretion of albumin > or = 20 and <200µg/min in at least 2 out of 3 urine samples.

RESULTS:

Nine (24.3 per cent) patients were microalbuminuric. Ambulatory blood pressure monitoring in the microalbuminuric patients had higher mean pressure values, mainly the systolic pressure, during sleep as compared with that in the normoalbuminuric patients (120.1 + or - 8.3 vs 110.8 + or - 7.1 mmHg; p=0.007). The pressure load was higher in the microalbuminuric individuals, mainly the systolic pressure load during wakefulness [6.3 (2.9-45.9) vs 1.6 (0-16 per cent); p=0.001]. This was the variable that better correlated with the urinary excretion of albumin (rS=0.61; p<0.001). Systolic pressure load >50 per cent and diastolic pressure load > 30 per cent during sleep was associated with microalbuminuria (p=0.008). The pressure drop during sleep did not differ between the groups.

CONCLUSION:

Microalbuminuric normotensive insulin-dependent diabetic patients show greater mean pressure value and pressure load during ambulatory blood pressure monitoring, and these variables correlate with urinary excretion of albumin.
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Blood Pressure / Blood Pressure Monitoring, Ambulatory / Diabetes Mellitus, Type 1 / Albuminuria Type of study: Diagnostic study Limits: Adult / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR

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Full text: Available Index: LILACS (Americas) Main subject: Blood Pressure / Blood Pressure Monitoring, Ambulatory / Diabetes Mellitus, Type 1 / Albuminuria Type of study: Diagnostic study Limits: Adult / Female / Humans / Male Language: English / Portuguese Journal: Arq. bras. cardiol Journal subject: Cardiology Year: 2000 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade do Estado do Rio de Janeiro/BR