Monitorizaçäo ambulatorial da pressäo arterial e microalbuminúria em diabéticos insulino-dependentes normotensos / Ambulatory blood pressure monitoring and microalbuminuria in normotensive subjects with insulin-dependent diabetes mellitus
Arq. bras. cardiol
;
75(3): 195-204, set. 2000. tab
Article
in Portuguese, English
| LILACS
| ID: lil-274140
RESUMO
OBJECTIVE:
To assess the association between microalbuminuria with ambulatory blood pressure monitoring in normotensive individuals with insulin-dependent diabetes mellitus.METHODS:
Thirty-seven patients underwent determination of the rate of urinary excretion of albumin through radioimmunoassay and ambulatory blood pressure monitoring. Their mean age was 26.5 + or - 6.7 years, and the mean duration of their disease was 8 (1-34) years. Microalbuminuria was defined as urinary excretion of albumin > or = 20 and <200µg/min in at least 2 out of 3 urine samples.RESULTS:
Nine (24.3 per cent) patients were microalbuminuric. Ambulatory blood pressure monitoring in the microalbuminuric patients had higher mean pressure values, mainly the systolic pressure, during sleep as compared with that in the normoalbuminuric patients (120.1 + or - 8.3 vs 110.8 + or - 7.1 mmHg; p=0.007). The pressure load was higher in the microalbuminuric individuals, mainly the systolic pressure load during wakefulness [6.3 (2.9-45.9) vs 1.6 (0-16 per cent); p=0.001]. This was the variable that better correlated with the urinary excretion of albumin (rS=0.61; p<0.001). Systolic pressure load >50 per cent and diastolic pressure load > 30 per cent during sleep was associated with microalbuminuria (p=0.008). The pressure drop during sleep did not differ between the groups.CONCLUSION:
Microalbuminuric normotensive insulin-dependent diabetic patients show greater mean pressure value and pressure load during ambulatory blood pressure monitoring, and these variables correlate with urinary excretion of albumin.
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Blood Pressure
/
Blood Pressure Monitoring, Ambulatory
/
Diabetes Mellitus, Type 1
/
Albuminuria
Type of study:
Diagnostic study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade do Estado do Rio de Janeiro/BR
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