Efeitos do Losartan sobre a remodelaçäo ventricular no infarto experimental em ratos / Effects of losartan on ventricular remodeling in experimental infarction in rats
Arq. bras. cardiol
;
75(6): 459-70, Dec. 2000. ilus, tab
Article
in Portuguese, English
| LILACS
| ID: lil-275430
ABSTRACT
OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22 percent, and NT = 47 percent (p<0.05). Ventricular mass,(VM/BM, mg/g) was 4.14 + or - 0.76 and 3.54 degrees 0.48, in the NT and LO groups, respectively (p<0.05). HOP (median) was 4.92 upsilong/mg in the LO and 5.54 upsilong/g in the NT group (p>0.05). The V0/LV values (median) were 0.24 mL/g in group LO and 0.31 mL/g in group NT (p<0.05) compared to NT group. There were no differences between the groups for +dp/dt and -dp/dt parameters. CONCLUSION: 1- The use of losartan myocardial infarction causes an attenuation of ventricular remodeling, bringing about an increased survival, an attenuation of ventricular hypertrophy and dilation, and an improvement of the isovolumetric pressure; 2- the treatment does not modify the myocardial collagen concentration
Full text:
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Index:
LILACS (Americas)
Main subject:
Losartan
/
Ventricular Remodeling
/
Myocardial Infarction
/
Antihypertensive Agents
Type of study:
Observational study
Limits:
Animals
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2000
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
UNESP/BR
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