Stability studies of tolbutamide/ß-cyclodextrin inclusion complexes
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
36(1): 111-20, jan.-jun. 2000. tab, graf
Article
in English
| LILACS
| ID: lil-276140
RESUMO
The ability of cyclodextrins to encapsulate many molcecules is used to improve the properties of drugs. Complexes of tolbutamide with ß-cyclodextrin were prepared by coprecipitation, kneading and freeze-drying. The inclusion complexes were stored under controlled conditions at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent relative humidity. The influence of temperature and the humidity was examined by performing DSC thermal analysis, X-ray diffractometry, Raman spectroscopy and dissolution rate measurements. The results indicated that the interactions and dissolution rate of TBM/ß-CD inclusion complexes obtained by coprecipitation and kneading were unchanged after storage at 5ºC, 40ºC, 50ºC and 40ºC/75 per cent RH over six months...
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Index:
LILACS (Americas)
Main subject:
Tolbutamide
/
Cyclodextrins
/
Drug Stability
Language:
English
Journal:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Journal subject:
Biochemistry
/
Pharmacy
/
Pharmacology
Year:
2000
Type:
Article
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