Alteraçöes do perfil das subfraçöes de lipoproteínas associadas à terapia de reposiçäo hormonal / Changes in the profile of lipoprotein subfractions associated with hormone replacement therapy
Arq. bras. cardiol
;
76(3): 177-88, Mar. 2001. tab, graf
Article
in Portuguese, English
| LILACS
| ID: lil-281413
ABSTRACT
OBJECTIVE: To report the effects of 2 regimens of hormone replacement therapy during the postmenopausal period on the profile of the major lipoprotein subfractions (HDL, LDL, and VLDL). METHODS: We carried out a cohort study in 38 postmenopausal patients who were starting their hormone replacement therapy due to gynecological indications, for a period of 12 weeks. Analysis of lipoprotein subclasses was performed through nuclear magnetic resonance spectroscopy. RESULTS: Hormone replacement therapy cause an increase in the proportion of larger subfractions of VLDL and HDL (p=0.008 and 0.03, respectively) and in the proportion of larger particles of VLDL due to a 36 percent increase in the levels of larger particles (p=0.004), concomitantly with a 15 percent reduction in the levels of smaller particles (p=0.04). In regard to HDL, the increase occurred only a 17 percent increase in the levels of larger particles (p=0.002). No significant change occurred in the distribution pattern of LDL subfractions. CONCLUSION: The proportion of larger subfractions of VLDL and HDL increases after hormone replacement therapy. The increase in the proportion of larger particles of VLDL occurs due to an increase in the levels of the larger subclasses concomitantly with a reduction in the smaller particles. However, an increase in the proportion of larger particles of HDL occurs only due to an increase in the levels of the larger subfractions
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Estrogen Replacement Therapy
/
Lipoproteins
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Female
/
Humans
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Fundação Universitária de Cardiologia/BR
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