Pharmacological differences between memory consolidation of habituation to an open field and inhibitory avoidance learning
Braz. j. med. biol. res
;
34(2): 233-240, Feb. 2001.
Article
in English
| LILACS
| ID: lil-281601
ABSTRACT
Rats implanted bilaterally with cannulae in the CA1 region of the dorsal hippocampus or the entorhinal cortex were submitted to either a one-trial inhibitory avoidance task, or to 5 min of habituation to an open field. Immediately after training, they received intrahippocampal or intraentorhinal 0.5-æl infusions of saline, of a vehicle (2 percent dimethylsulfoxide in saline), of the glutamatergic N-methyl-D-aspartate (NMDA) receptor antagonist 2-amino-5-phosphono pentanoic acid (AP5), of the protein kinase A inhibitor Rp-cAMPs (0.5 æg/side), of the calcium-calmodulin protein kinase II inhibitor KN-62, of the dopaminergic D1 antagonist SCH23390, or of the mitogen-activated protein kinase kinase inhibitor PD098059. Animals were tested in each task 24 h after training. Intrahippocampal KN-62 was amnestic for habituation; none of the other treatments had any effect on the retention of this task. In contrast, all of them strongly affected memory of the avoidance task. Intrahippocampal Rp-cAMPs, KN-62 and AP5, and intraentorhinal Rp-cAMPs, KN-62, PD098059 and SCH23390 caused retrograde amnesia. In view of the known actions of the treatments used, the present findings point to important biochemical differences in memory consolidation processes of the two tasks
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Avoidance Learning
/
Calcium-Calmodulin-Dependent Protein Kinases
/
Excitatory Amino Acid Agonists
/
1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine
/
Enzyme Inhibitors
/
Habituation, Psychophysiologic
/
Memory
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2001
Type:
Article
Affiliation country:
Argentina
/
Brazil
Institution/Affiliation country:
Universidad de Buenos Aires/AR
/
Universidade Federal do Rio Grande do Sul/BR
Similar
MEDLINE
...
LILACS
LIS