RNA and DNA aptamers as potential tools to prevent cell adhesion in disease
Braz. j. med. biol. res
;
34(3): 295-300, Mar. 2001. ilus
Article
in English
| LILACS
| ID: lil-281609
RESUMO
Recent research has shown that receptor-ligand interactions between surfaces of communicating cells are necessary prerequisites for cell proliferation, cell differentiation and immune defense. Cell-adhesion events have also been proposed for pathological conditions such as cancer growth, metastasis, and host-cell invasion by parasites such as Trypanosoma cruzi. RNA and DNA aptamers (aptus = Latin, fit) that have been selected from combinatorial nucleic acid libraries are capable of binding to cell-adhesion receptors leading to a halt in cellular processes induced by outside signals as a consequence of blockage of receptor-ligand interactions. We outline here a novel approach using RNA aptamers that bind to T. cruzi receptors and interrupt host-cell invasion in analogy to existing procedures of blocking selectin adhesion and function in vitro and in vivo
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Trypanosoma cruzi
/
DNA
/
RNA
/
Cell Adhesion Molecules
/
RNA-Binding Proteins
Limits:
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2001
Type:
Article
/
Congress and conference
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Säo Paulo/BR
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