Effects of milk from goat fed Crotalaria spectabilis seeds on growing rats
Braz. j. vet. res. anim. sci
; 36(2): 97-100, 1999. ilus, tab
Article
in En
| LILACS
| ID: lil-283497
Responsible library:
BR68.1
ABSTRACT
Seeds of Crotalaria spectabilis, containing the pyrrolizidine alkaloid (PA) monocrotaline (MCT), were fed to a lactating dairy goat. Milk from this goat was fed to rats for 8 weeks to determine whether MCT or its toxic metabolites are transferred into the goat's milk. Rats from the experimental group showed significantly higher (p<0.05) serum levels of ALT, AST, GGT and LDH and less weight gains (p<0.05) than control rats. The most significant lesions in rats consuming the experimental ration were mild to moderate interstitial pneumonia and a vacuolar degeneration and occasionally necrosis of periportal hepatocytes. The results of this study indicate that the PA and/or its metabolites are eliminated in milk
Full text:
1
Index:
LILACS
Main subject:
Poisoning
/
Pyrrolizidine Alkaloids
/
Milk
Limits:
Animals
Language:
En
Journal:
Braz. j. vet. res. anim. sci
Journal subject:
MEDICINA VETERINARIA
Year:
1999
Type:
Article