APOE epsilon4 and Alzheimer's disease: positive association in a Colombian clinical series and review of the Latin-American studies
Arq. neuropsiquiatr
;
59(1): 11-17, Mar. 2001. tab
Article
in English
| LILACS
| ID: lil-284230
RESUMO
OBJECTIVE:
As the strength of the association between the APOE epsilon4 allele and Alzheimer's disease (AD) varies across ethnic groups, we studied if there was such an association in Colombian patients.METHOD:
We performed apolipoprotein E (APOE) genotyping in a clinical sample of 83 unrelated AD patients, predominantly late-onset (>65 yrs) including familial ( n =30) and sporadic AD cases (n= 53) diagnosed according to NINCDS-ADRDA criteria and assessed by a multi-disciplinary team. Control subjects (n = 44) had no significant cognitive impairment by medical interview and neuro-psychological testing.RESULTS:
We found a high association (OR= 5.1 95 percentCI 1.9 -13.6) between APOE epsilon4 and AD, in this series with predominantly late-onset cases with familial aggregation in 24 cases (28.9 percent). A significant negative association was found between epsilon2 and AD (OR= 0.2 95 percent CI 0.05-0.75).CONCLUSION:
Further population-based surveys in Colombia are warranted to precise a possible dose effect of APOE epsilon4
Full text:
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Index:
LILACS (Americas)
Main subject:
Apolipoproteins E
/
Alzheimer Disease
Type of study:
Diagnostic study
/
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Arq. neuropsiquiatr
Journal subject:
Neurology
/
Psychiatry
Year:
2001
Type:
Article
/
Project document
Affiliation country:
Belgium
/
Colombia
Institution/Affiliation country:
Flanders Interuniversity Institute for Biotechnology/BE
/
Instituto Nacional de Salud/CO
/
Universidad Javeriana/CO
/
University of Antwerp/BE
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