Total plasma homocysteine concentrations in Puerto Rican patients with presumptive atherosclerotic coronary disease
P. R. health sci. j
;
19(3): 253-8, Sept. 2000. ilus, tab, graf
Article
in English
| LILACS
| ID: lil-285526
RESUMO
BACKGROUND:
In Puerto Rico, it has been established that although coronary heart disease is the leading cause of death, the population has a lower incidence of coronary disease than the continental United States. In addition, the severity of the disease is less aggressive in terms of a lower incidence of ventricular tachycardia and sudden death. A factor in the lower incidence of coronary disease in Puerto Rico could be a lower total plasma homocysteine concentration (tHcys) in our population.METHODS:
We randomly measured tHcys concentrations in seventy-two Hispanic patients who were hospitalized for coronary angiography at the Cardiovascular Center of Puerto Rico and the Caribbean (UPR Division).RESULTS:
The mean tHCys concentration in our patient population is similar than that reported for the Framingham study when adjusted by age (11.2 mumol/L vs. 11.8 mumol/L). In the Puerto Rican population, males had a higher tHcys concentration than females but this difference was not statistically significant (10.9 mumol/L vs. 9.4 mumol/L, p = 0.09). In addition, we did not see an increase of tHcys concentrations in diabetic patients when compared with nondiabetics (10.1 mumol/L vs. 10.3 mumol/L, p = 0.73). Neither we saw a direct correlation between tHcys concentrations and atherosclerosis as measured by coronary angiography (normal = 10.9 mumol/L, mild = 8.6 mumol/L, moderate = 10.9 mumol/L, severe = 10.5 mumol/L; ANOVA = 0.29).CONCLUSIONS:
These results suggest that tHcys concentration is not a good predictor of atherosclerotic coronary disease in our patient population.
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Index:
LILACS (Americas)
Main subject:
Coronary Artery Disease
/
Homocysteine
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Caribbean
/
Puerto Rico
Language:
English
Journal:
P. R. health sci. j
Journal subject:
Medicine
Year:
2000
Type:
Article
Affiliation country:
Puerto Rico
Institution/Affiliation country:
University of Puerto Rico/PR
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