Factors affecting Helicobacter pylori eradication using a seven-day triple therapy with a proton pump inhibitor, tinidazole and clarithromycin, in brazilian patients with peptic ulcer
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
;
56(1): 11-16, Jan.-Feb. 2001. tab
Article
in English
| LILACS
| ID: lil-285569
RESUMO
Triple therapy is accepted as the treatment of choice for H. pylori eradication. In industrialized countries, a proton pump inhibitor plus clarithromycin and amoxicillin or nitroimidazole have shown the best results. Our aims were 1. To study the eradication rate of the association of a proton pump inhibitor plus tinidazole and clarithromycin on H. pylori infection in our population. 2. To determine if previous treatments, gender, age, tobacco, alcohol use, and non-steroidal anti-inflammatory drugs (NSAIDs) change the response to therapy. METHODS:
Two hundred patients with peptic ulcer (upper endoscopy) and H. pylori infection (histology and rapid urease test - RUT) were included. A proton pump inhibitor (lansoprazole 30 mg or omeprazole 20 mg), tinidazole 500 mg, and clarithromycin 250 mg were dispensed twice a day for a seven-day period. Eradication was assessed after 10 to 12 weeks of treatment through histology and RUT.RESULTS:
The eradication rate of H. pylori per protocol was 65 percent (128/196 patients). This rate was 53 percent for previously treated patients, rising to 76 percent for not previously treated patients, with a statistical difference p<0.01. No significant difference was observed regarding sex, tobacco use, alcohol consumption, and NSAID use, but for elderly patients the difference was p = 0.05. Adherence to treatment was good, and side effects were mild.CONCLUSIONS:
A proton pump inhibitor, tinidazole, and clarithromycin bid for seven days resulted in H. pylori eradication in 65 percent of the patients. Previous treatments were the main cause of treatment failure
Full text:
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Index:
LILACS (Americas)
Main subject:
Peptic Ulcer
/
Tinidazole
/
Helicobacter pylori
/
Helicobacter Infections
/
Proton Pumps
/
Clarithromycin
/
Anti-Bacterial Agents
Type of study:
Practice guideline
/
Prognostic study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Aged80
/
Female
/
Humans
/
Male
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Rev. Hosp. Clin. Fac. Med. Univ. Säo Paulo
Journal subject:
Medicine
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
University of Säo Paulo/BR
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