Comparaçäo entre os efeitos da clortalidona e do diltiazem sobre a isquemia miocárdica em idosos hipertensos portadores de doença arterial coronariana / Effects of chlorthalidone and diltiazem on myocardial ischemia in elderly patients with hypertension and coronary artery disease
Arq. bras. cardiol
;
76(4): 263-72, abr. 2001. tab
Article
in Portuguese, English
| LILACS
| ID: lil-285830
ABSTRACT
OBJECTIVE:
Antihypertensive therapy with thiazides decreases coronary events in elderly patients. However, the influence of diuretics on myocardial ischemia has not been fully investigated. The aim of this study was to compare the effect of chlorthalidone and diltiazem on myocardial ischemia.METHODS:
Following a randomized, double-blind, crossover protocol, we studied 15 elderly hypertensive patients aged 73.6 + or - 4.6 years with myocardial ischemia. All patients had angiographically documented coronary artery disease. We measured patients using 48- hour ambulatory electrocardiogram monitoring and exercise testing. After a 2-week period using placebo, patients received chlorthalidone or diltiazem for 4 weeks.RESULTS:
Both treatments lowered systolic and diastolic blood pressures...
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Diltiazem
/
Chlorthalidone
/
Myocardial Ischemia
/
Diuretics
/
Hypertension
/
Antihypertensive Agents
Type of study:
Controlled clinical trial
/
Practice guideline
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
/
Portuguese
Journal:
Arq. bras. cardiol
Journal subject:
Cardiology
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade de Säo Paulo/BR
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