Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins
Braz. j. med. biol. res
;
34(5): 555-566, May 2001. ilus, tab
Article
in English
| LILACS
| ID: lil-285869
ABSTRACT
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators
Full text:
Available
Index:
LILACS (Americas)
Main subject:
Anti-Inflammatory Agents, Non-Steroidal
/
Aspirin
/
Hydroxyeicosatetraenoic Acids
/
Inflammation Mediators
/
Inflammation
/
Lipids
Limits:
Animals
/
Humans
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2001
Type:
Article
/
Project document
Affiliation country:
United States
Institution/Affiliation country:
Harvard Medical School/US
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