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In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe
Barbosa, Theolis; Arruda, Sérgio; Cavada, Benildo; Grangeiro, Thalles Barbosa; Freitas, Luiz Antônio Rodrigues de; Barral-Netto, Manoel.
  • Barbosa, Theolis; Fundaçäo do Instituto Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador. BR
  • Arruda, Sérgio; Fundaçäo do Instituto Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador. BR
  • Cavada, Benildo; Universidade Federal do Ceará. Centro de Ciências. Fortaleza. BR
  • Grangeiro, Thalles Barbosa; Universidade Federal do Ceará. Centro de Ciências. Fortaleza. BR
  • Freitas, Luiz Antônio Rodrigues de; Fundaçäo do Instituto Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador. BR
  • Barral-Netto, Manoel; Fundaçäo do Instituto Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador. BR
Mem. Inst. Oswaldo Cruz ; 96(5): 673-678, July 2001. ilus, graf
Article in English | LILACS | ID: lil-289355
RESUMO
This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects
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Full text: Available Index: LILACS (Americas) Main subject: Lymphocyte Activation / Apoptosis / Lectins / Fabaceae / Lymph Nodes Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundaçäo do Instituto Oswaldo Cruz/BR / Universidade Federal do Ceará/BR

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Full text: Available Index: LILACS (Americas) Main subject: Lymphocyte Activation / Apoptosis / Lectins / Fabaceae / Lymph Nodes Limits: Animals Language: English Journal: Mem. Inst. Oswaldo Cruz Journal subject: Tropical Medicine / Parasitology Year: 2001 Type: Article / Project document Affiliation country: Brazil Institution/Affiliation country: Fundaçäo do Instituto Oswaldo Cruz/BR / Universidade Federal do Ceará/BR