Skin reactions to thimerosal and Leishmania in dogs from a leishmaniasis endemic area: it is better to keep them apart
Mem. Inst. Oswaldo Cruz
;
96(5): 679-681, July 2001. tab
Article
in English
| LILACS
| ID: lil-289356
RESUMO
Positive Montenegro's skin test is a delayed type hypersensitivity reaction widely used as indicative of previous infection with Leishmania in both humans and dogs. Montenegro's antigen consists of a crude Leishmania antigen solution, usually containing thimerosal as preserving agent. In this work it is shown that a large proportion of dogs (11 out of 56) examined in an endemic area of leishmaniasis presented induration at the site of injection of a diluent containing thimerosal alone. This clearly demonstrates that thimerosal leads to a high number of false positive skin reactions in dogs and that its use in Montenegro's skin test antigenic preparations should be avoided
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Index:
LILACS (Americas)
Main subject:
Preservatives, Pharmaceutical
/
Skin
/
Thimerosal
/
Leishmaniasis
/
Dog Diseases
/
Leishmania
Type of study:
Diagnostic study
Limits:
Animals
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Mem. Inst. Oswaldo Cruz
Journal subject:
Tropical Medicine
/
Parasitology
Year:
2001
Type:
Article
/
Project document
Affiliation country:
Brazil
Institution/Affiliation country:
Centro de Referência em Doenças Endêmicas Pirajá da Silva/BR
/
Fundaçäo do Instituto Oswaldo Cruz/BR
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