Regulation of the renal proximal tubule second sodium pump by angiotensins
Braz. j. med. biol. res
;
34(8): 1079-1084, Aug. 2001. ilus
Article
in English
| LILACS
| ID: lil-290157
RESUMO
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption
Full text:
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Index:
LILACS (Americas)
Main subject:
Sodium
/
Angiotensin I
/
Angiotensin II
/
Sodium-Potassium-Exchanging ATPase
/
Extracellular Space
/
Kidney Tubules, Proximal
Limits:
Animals
Language:
English
Journal:
Braz. j. med. biol. res
Journal subject:
Biology
/
Medicine
Year:
2001
Type:
Article
Affiliation country:
Brazil
Institution/Affiliation country:
Universidade Federal do Rio de Janeiro/BR
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