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Heterogeneous response of adipose tissue to cancer cachexia
Bertevello, P. S; Seelaender, M. C. L.
  • Bertevello, P. S; Universidade de Säo Paulo. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Säo Paulo. BR
  • Seelaender, M. C. L; Universidade de Säo Paulo. Instituto de Ciências Biomédicas. Departamento de Histologia e Embriologia. Säo Paulo. BR
Braz. j. med. biol. res ; 34(9): 1161-1167, Sept. 2001. ilus, tab
Article in English | LILACS | ID: lil-290397
ABSTRACT
Cancer cachexia causes disruption of lipid metabolism. Since it has been well established that the various adipose tissue depots demonstrate different responses to stimuli, we assessed the effect of cachexia on some biochemical and morphological parameters of adipocytes obtained from the mesenteric (MES), retroperitoneal (RPAT), and epididymal (EAT) adipose tissues of rats bearing Walker 256 carcinosarcoma, compared with controls. Relative weight and total fat content of tissues did not differ between tumor-bearing rats and controls, but fatty acid composition was modified by cachexia. Adipocyte dimensions were increased in MES and RPAT from tumor-bearing rats, but not in EAT, in relation to control. Ultrastructural alterations were observed in the adipocytes of tumor-bearing rat RPAT (membrane projections) and EAT (nuclear bodies)
Subject(s)
Full text: Available Index: LILACS (Americas) Main subject: Cachexia / Carcinoma 256, Walker / Adipose Tissue / Adipocytes Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Säo Paulo/BR

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Full text: Available Index: LILACS (Americas) Main subject: Cachexia / Carcinoma 256, Walker / Adipose Tissue / Adipocytes Limits: Animals Language: English Journal: Braz. j. med. biol. res Journal subject: Biology / Medicine Year: 2001 Type: Article Affiliation country: Brazil Institution/Affiliation country: Universidade de Säo Paulo/BR